抗菌薬投与は小児の若年性特発性関節炎（JIA）のリスクを高める

http://pediatrics.aappublications.org/content/136/2/e333.abstract?etoc

Antibiotic Exposure and Juvenile Idiopathic Arthritis: A Case–Control Study

Daniel B. Horton, Frank I. Scott, Kevin Haynes, Mary E. Putt, Carlos D. Rose, James D. Lewis, and Brian L. Strom

Pediatrics 2015; 136:e333-e343

odds ratio: 2.1

dose dependent

5 antibiotic courses: 3.0

strongest for exposures within 1 year of diagnosis

did not substantively change when adjusting for number or type of infections.

In contrast, nonbacterial antimicrobial agents (eg, antifungal, antiviral) were not associated with JIA.

In addition, antibiotic-treated upper respiratory tract infections were more strongly associated with JIA than untreated upper respiratory tract infections.