Antibiotic Exposure and Juvenile Idiopathic Arthritis: A Case–Control Study
Daniel B. Horton, Frank I. Scott, Kevin Haynes, Mary E. Putt, Carlos D. Rose, James D. Lewis, and Brian L. Strom
Pediatrics 2015; 136:e333-e343
odds ratio: 2.1
5 antibiotic courses: 3.0
strongest for exposures within 1 year of diagnosis
did not substantively change when adjusting for number or type of infections.
In contrast, nonbacterial antimicrobial agents (eg, antifungal, antiviral) were not associated with JIA.
In addition, antibiotic-treated upper respiratory tract infections were more strongly associated with JIA than untreated upper respiratory tract infections.