Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies
Dietary sodium intake and mortality: the National Health and Nutrition Examination Survey (NHANES I)
Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events
Long Term Intake of Miso Soup Unaffected Blood Pressure in Subjects
with Normal or StageⅠ Hypertension
－Double Blind Comparative Intervention Trial－
Objective The present study aimed at investigating the effects of newly developed Miso with potent ACE inhibition on blood pressure and its safety in 39 subjects aged 20-65 years with normotension or stageⅠ hypertension along with conventional Shinshu Miso.
Methods A double-blind parallel-group study was conducted, and the subjects were allocated into newly developed Miso（N）or Shinshu Miso（C）. They were served two cups of Miso soup a day（32 g Miso; 3.7-3.8 g salt）. Blood pressure and the changes of metabolism were investigated.
Results N group tended to decrease blood pressures throughout the study while consuming 3.8 g more salt due to the Miso soup. In N group, Ccr significantly decreased within the normal range. The Miso did not influence lipid and glucose metabolism. In C group blood pressure was unchanged with the Miso intake. Neither LDL-cholesterol nor triglyceride was changed. Interestingly, hANP was slightly increased in C Miso.
Conclusions This is the first intervention trial in humans suggesting that long-term Miso intake with salt intake does not increase blood pressures and that some antihypertensive constituents occur in Miso as reported in our previous animal studies. hANP increase might be related to natriuresis of Shinshu Miso reported.